Mount Sinai Scientists Identify First Gene Linked to Heart Muscle...

Findings Show Several FDA-Approved Drugs May also be Effective in Patients Diagnosed with Dilated Cardiomyopathy(PRWeb April 28, 2014)Read the full story at
Source: PRWeb: Medical Pharmaceuticals - Category: Pharmaceuticals Source Type: news

Related Links:

Conclusions: According to this systematic review of the literature, data related to exercise therapy specifically for patients with DCM are scarce and exercise interventions in articles reviewed were prescribed differently using the FITT (frequency, intensity, time, and type) principle. Exercise intensity tailored to individual exercise capacity should be used for optimal exercise prescriptions that are safe and efficacious in patients with DCM.
Source: Journal of Cardiopulmonary Rehabilitation - Category: Rehabilitation Tags: Systematic Review Source Type: research
AbstractPurpose of reviewThis review summarizes the clinical characteristics and updated outcomes of primary pediatric cardiomyopathies including dilated (DCM), hypertrophic (HCM), and restrictive cardiomyopathy (RCM), and briefly discusses left ventricular non-compaction (LVNC) and arrhythmogenic cardiomyopathy (ACM), primarily arrythmogenic right ventricular cardiomyopathy (ARVC).Recent findingsPediatric cardiomyopathies are diseases of the heart muscle with an estimated annual incidence of 1.1 –1.5 cases per 100,000. They are progressive in nature and are frequently caused by a genetic mutation causing a structura...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Conclusion Using a computational drug-repositioning approach based on the integration of publicly available gene expression signatures of drugs and diseases, sirolimus was suggested as a novel therapeutic option for inflammatory dilated cardiomyopathy. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Drug Research - Category: Drugs & Pharmacology Authors: Tags: Original Article Source Type: research
We present the case of an infant with end-stage dilated cardiomyopathy and intractable heart failure who received pulmonary artery banding. Serial follow-up through two-dimensional and three-dimensional echocardiography revealed gradual improvement in the left ventricular ejection fraction and favorable remodeling. The result of three-dimensional speckle tracking suggested that this benefit is associated with improvements in global strain and intraventricular dyssynchrony.
Source: Pediatric Cardiology - Category: Cardiology Source Type: research
Background: Dilated cardiomyopathy (DCM) is the leading indication for heart transplantation in New Zealand (NZ). The familial subtype (FDCM) is aggressive, presents early, and is implicated in up to 50% of idiopathic DCM (IDCM). Diagnosis requires an affected individual having ≥2 affected close relatives. Adequate family pedigree analysis is diagnostically essential, and screening relatives is imperative as pre-symptomatic therapy improves outcomes. We utilised a validated family history survey to screen our NZ heart transplant population for FDCM more systematically.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 088 Source Type: research
Activation of ErbB4 by neuregulin 1 (NRG1) promotes cardiomyocyte hypertrophy and proliferation in mice, while deletion of ErbB4 from cardiomyocytes mid-gestation results in development of dilated cardiomyopathy and reduced survival. However, the role of ErbB4 in the heart after maturation remained unknown. Thus, we deleted ErbB4 in αMHC-MerCreMer (cCre Tg+/)/ErbB4 homozygote floxed (ErbB4 fl/fl) mice at ∼2 months of age with 10 injections of Tamoxifen (20mg/kg/day). Contractile function was reduced in vivo (echocardiography, 16%) and ex vivo (isolated-perfused, 33%) 3 months after gene deletion, while survival i...
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 070 Source Type: research
In this study we compare outcomes in patients with DCM with and without LGE.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 062 Source Type: research
Truncating variants in the TTN gene (TTNtv) are common in dilated cardiomyopathy (DCM) patients (15 –20% cases) but are also present in unaffected individuals in DCM families and in the general population. Interpreting the clinical significance of these variants is challenging.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 018 Source Type: research
Background: The prevalence of atrial fibrillation (AF) has not been well described in young patients with inherited heart diseases such as the inherited cardiomyopathies: hypertrophic cardiomyopathy (HCM), familial dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), left ventricular non-compaction (LVNC); or inherited arrhythmia syndromes including long QT syndrome (LQTS), Brugada syndrome (BrS) or catecholaminergic polymorphic ventricular tachycardia (CPVT).
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 455 Source Type: research
ConclusionsThe change of slope was dependent on surgical procedures. In functional mitral regurgitation, the slope may be a more sensitive parameter in reflecting the left ventricular contractile function than the left ventricular ejection fraction.
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
More News: Cardiology | Cardiomyopathy | Dilated Cardiomyopathy | Genetics | Heart | Pharmaceuticals