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Effect of Rambutan-honey and its Flavonoid on TGF-β1 Induce Fibroplasia Oral Wound Healing

Background and Objective: The TGF-β1 is a multifunctional cytokine that contributes fibroplasia wound healing via mechanisms that involved free radicals. Honey has been succesfully used for treating wound healing. It’s has an antioxidant, anti-inflammatory, antibacterial and debridement effects. The antioxidant substances such as flavonoid can reduce free radicals-malondialdehyde (MDA) on rats skin wound healing. However, the mechanisms of its action at stress oxidative oral mucosa wound healing have poorly understood. The purpose of this study are to investigate the effect of rambutan-honey topical induce fibroplasia wound healing by TGF-β1 inhibit MDA formation oral mucous rats wound healing and to identify the presence of flavonoid components responsible effect. Materials and Methods: The research methods were an experimental laboratory. The samples (n = 16 group–1) were divided into negative control, positive control φ4±2 mm wound, 1 mL rambutan-honey wound and 0.1 mL ascorbic acid. Oral mucous wound were observed on day 0, 3, 7, 14. The production of TGF-β1 determined by ELISA reader. Bradford assay used for calculating protein concentration. The HPLC analysis was performed in order to identify rutin and myricetin on honey samples. The productions of free radicals were determined by MDA tissues level and fibroblast numbers that determined by histology examination and statistically analyzed (ANOVA, Tukey’s, p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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