Prognostic biomarkers to identify patients destined to develop severe Crohn ’s disease who may benefit from early biological therapy: protocol for a systematic review, meta-analysis and external validation

DiscussionIf this systematic review and meta-analysis identifies biomarkers that appear sufficiently predictive for subsequent severe disease course, we aim to combine them in a predictive model, followed by external validation using individual patient data. A predictive model able to identify new presentations of Crohn ’s disease destined to develop severe disease subsequently would have considerable clinical utility for patient management.Systematic review registrationPROSPEROCRD42016029363.
Source: Systematic Reviews - Category: Global & Universal Source Type: research