Pathogen –Host Interaction of Histoplasma capsulatum : an Update

AbstractPurpose of ReviewHistoplasma capsulatum is a dimorphic fungus endemic to the Americas but is increasingly recognized as a global pathogen. In this review, we describe the most current findings in host evasion, host –pathogen interaction, therapeutics, and vaccines.Recent FindingsRecent advances in the understanding ofH. capsulatum virulence and immunity include the importance of host –pathogen nutrient modulation, immune cell transcriptional regulators, cytokine signaling, and coordination of innate and adaptive immunity.SummaryThe latest developments in our understanding ofH. capsulatum infection lay the foundation for future clinical breakthroughs in prevention, diagnosis, and treatment of this intracellular fungal pathogen.
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research