ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma

This study identifies an ERK-dependent mechanism that drives PREX1 upregulation and subsequent RAC1-dependent invasion in BRAF- and NRAS-mutant melanoma. Mol Cancer Res; 14(10); 1009–18. ©2016 AACR.

Source: Molecular Cancer Research - October 12, 2016 Category: Cancer & Oncology Authors: Ryan, M. B., Finn, A. J., Pedone, K. H., Thomas, N. E., Der, C. J., Cox, A. D. Tags: Signal Transduction Source Type: research