mtDNA diversity in human populations highlights the merit of haplotype matching in gene therapies

We report ranges and mean differences for all statistics to quantify uncertainty in our results. LIMITATIONS/REASONS FOR CAUTION The mapping from mouse and other mammalian models to the human system is challenging, as timescales and mechanisms may differ. Reporting biases in NCBI mtDNA data, if present, may affect the statistics we compute. We discuss the robustness of our findings in the light of these concerns. WIDER IMPLICATIONS OF THE FINDINGS Matching the mtDNA haplotypes of the mother and third-party donor in mitochondrial replacement therapies is supported as a means of ameliorating the potentially deleterious results of human mtDNA diversity. We present a chart of expected SNP differences between mtDNA haplogroups, allowing the selection of optimal partners for therapies. LARGE SCALE DATA N/A STUDY FUNDING/COMPETING INTERESTS The authors report no external funding sources or conflicts of interest.
Source: Molecular Human Reproduction - Category: Molecular Biology Authors: Tags: Original research Source Type: research