Rare aggressive behavior of MDM2-amplified retroperitoneal dedifferentiated liposarcoma, with brain, lung and subcutaneous metastases

We describe a case of retroperitoneal dedifferentiated liposarcoma in a 63-year-old male, who showedMDM2 amplification with fluorescencein situ hybridization, which displayed unusually aggressive behavior, with brain, lung and subcutaneous soft tissue metastases. As previous reports of metastatic liposarcoma have largely grouped DDL in with other (genetically and clinically distinct) liposarcoma subtypes, we highlight and discuss the rare occurrence of brain metastasis inMDM2-amplified retroperitoneal liposarcoma.
Source: Rare Tumors - Category: Cancer & Oncology Source Type: research