A Multivariate Risk Calculator for Multiple Sclerosis and Study of an Endophenotype in Siblings of People with Multiple Sclerosis (S34.002)

CONCLUSIONS:This risk score has the best AUC described to date. Siblings have an intermediate risk score, in keeping with their "at risk" position. Siblings with a high risk score have increased IL17 production, a potential endophenotypic marker.Study Supported by:Multiple Sclerosis Society of Great Britain and Northern IrelandDisclosure: Dr. Dobson has nothing to disclose. Dr. Topping has nothing to disclose. Dr. Chard holds stock and/or stock options in GlaxoSmithKline, Inc. Dr. Chard has received research support from the Multiple Sclerosis Society of Great Britain and Northern Ireland. Dr. Schmierer has received personal compensation for activities with Sanofi-Aventis Pharmaceuticals Inc., Novartis and Merck Serono. Dr. Smith has nothing to disclose. Dr. Ramagopalan has nothing to disclose. Dr. Giovannoni has received personal compensation for activities with Biogen Idec, Merck Serono, Vertex Pharmaceuticals, Bayer Schering, Pfizer Inc., Teva Neuroscience, and Sanofi-Aventis Pharmaceuticals Inc. Dr. Giovannoni has received research support from Biogen Idec, Merck Serono, Novartis, and Ironwood.

Source: Neurology - April 9, 2014 Category: Neurology Authors: Dobson, R., Topping, J., Chard, D., Schmierer, K., Smith, P., Ramagopalan, S., Giovannoni, G. Tags: MS and CNS Inflammatory Disease: Risk Factors for Multiple Sclerosis Disease and Course Source Type: research