External beam boost versus interstitial high-dose-rate brachytherapy boost in the adjuvant radiotherapy following breast-conserving therapy in early-stage breast cancer: a dosimetric comparison.

This study aims to compare the dosimetric data of local tumor's bed dose escalation (boost) with photon beams (external beam radiation therapy - EBRT) versus high-dose-rate interstitial brachytherapy (HDR-BT) after breast-conserving treatment in women with early-stage breast cancer. MATERIAL AND METHODS: We analyzed the treatment planning data of 136 irradiated patients, treated between 2006 and 2013, who underwent breast-conserving surgery and adjuvant whole breast irradiation (WBI; 50.4 Gy) and boost (HDR-BT: 10 Gy in one fraction [n = 36]; EBRT: 10 Gy in five fractions [n = 100]). Organs at risk (OAR; heart, ipsilateral lung, skin, most exposed rib segment) were delineated. Dosimetric parameters were calculated with the aid of dose-volume histograms (DVH). A non-parametric test was performed to compare the two different boost forms. RESULTS: There was no difference for left-sided cancers regarding the maximum dose to the heart (HDR-BT 29.8% vs. EBRT 29.95%, p = 0.34). The maximum doses to the other OAR were significantly lower for HDR-BT (Dmax lung 47.12% vs. 87.7%, p
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

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ConclusionABCB1 C3435T and ABCG2 C421A might represent a potential risk factor for breast cancer for Turkish women.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2020Source: Materials Science and Engineering: C, Volume 109Author(s): Liming Chen, Cuicui Zhang, Jiani Xiao, Jie You, Wei Zhang, Yu Liu, Liang Xu, Anwen Liu, Hongbo Xin, Xiaolei WangAbstractEarly diagnosis is the key to the good prognosis of breast cancer. At present, clinical tumor diagnosis is mainly through serum analysis, which is painful and can only detect relatively advanced tumors that have already metastasized from the glands into the blood circulation. Here, we developed an earlier diagnostic method (before tumor cells entering the blood) of breast cancers through a convenient and painles...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: 15 February 2020Source: Journal of Molecular Structure, Volume 1202Author(s): Salimeh Mirzaei, Farzin Hadizadeh, Farhad Eisvand, Fatemeh Mosaffa, Razieh GhodsiAbstractA new series of quinoline-chalcone hybrids was synthesized. The structures of these compounds were characterized by spectroscopic methods including 1H and 13CNMR and mass spectroscopy. The cytotoxic activity of compounds was evaluated against four human cancer cell lines including A2780 (human ovarian carcinoma) and A2780/RCIS (Cisplatin resistant human ovarian carcinoma), MCF-7 (human breast cancer cells), MCF-7/MX (Mitoxantrone resistant h...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 6 December 2019Source: Journal of Molecular LiquidsAuthor(s): Sudabeh Shokrollahi, Ahmad Amiri, Farzaneh Fadaei Tirani, Kurt Schenk-JoßAbstractFour new Schiff-bases have been synthesized from the 1:2 M condensation of 4,5,6,7-tetrahydrobenzothiazole-2,6-diamine with 2-hydroxybenzaldehyde (SL1), 5-Bromo-2-hydroxybenzaldehyde (SL2), 2-hydroxy-3-methoxybenzaldehyde (SL3) and 2-hydroxy-1-naphthaldehyde (SL4) and charactrised by UV–Vis, FT-IR, 1H NMR and mass spectroscopy. The crystal structures of SL1 and SL2 were determined by X-ray diffraction and the validity of gas-phase dft...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
In conclusion, it was shown that the inclusion of FBS in culture medium increased expression of EPOR in breast cancer cells and rHuEPO treatment had no effect on the proliferation of these cancer cells.
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 2 December 2019Source: Life SciencesAuthor(s): Yu-kun Li, Juan Zou, Dong-mei Ye, Ying Zeng, Chang-ye Chen, Gui-fang Luo, Xi ZengAbstractAn oncogenic role, p21-activated kinase 5 (PAK5), has proven as a significant mediator for many cellular progression, which is expressed highly in human organs such as lung, liver, kidney, blood vessels endothelial cells and inflammatory cells. PAK5 was primitively detected in the cerebrum and accelerated the filopodia formation in neurocytes. It can reverse the effect of Rho and adjust its activity to mediate maintenance and development of nerve axon by ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: January 2020Source: Academic Radiology, Volume 27, Issue 1Author(s): Lars J. Grimm, Maciej A. MazurowskiRadiogenomics is an area of research that aims to identify associations between imaging phenotypes (“radio-”) and tumor genome (“-genomics”). Breast cancer radiogenomics research in particular has been an especially prolific area of investigation in recent years as evidenced by the wide number and variety of publications and conferences presentations. To date, research has primarily been focused on dynamic contrast enhanced pre-operative breast MRI and breast cancer molecular sub...
Source: Academic Radiology - Category: Radiology Source Type: research
ConclusionWe developed the deep learning signatures for preoperative prediction of SLN metastasis status and numbers (1–2 or more than two metastatic SLN) in patients with breast cancer. The deep learning signature may potentially provide a noninvasive approach to assist clinicians in predicting SLN metastasis in patients with breast cancer.
Source: Academic Radiology - Category: Radiology Source Type: research
Conclusions: The XBP1 biochip enables isoform specific quantification of protein level changes upon activation and inhibition of IRE1α RNase activity, using a routine clinical methodology. As such it provides a research tool and potential clinical tool with a quantified, simultaneous, rapid output that is not available from any other published method. PMID: 31807121 [PubMed]
Source: Biological Procedures Online - Category: Molecular Biology Authors: Tags: Biol Proced Online Source Type: research
Cancer classification aims to provide an accurate diagnosis of the disease and prediction of tumor behavior to facilitate oncologic decision making. Traditional breast cancer classification, mainly based on clinicopathologic features and assessment of routine biomarkers, may not capture the varied clinical courses of individual breast cancers. The underlying biology in cancer development and progression is complicated. Recent findings from high-throughput technologies added important information with regard to the underlying genetic alterations and the biological events in breast cancer. The information provides insights i...
Source: Advances in Anatomic Pathology - Category: Pathology Tags: Review Articles Source Type: research
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