Impaired relaxation despite upregulated calcium-handling pro in atrial myocardium from type 2 diabetic patients with preserved ejection fraction
In patients with coronary disease and preserved ejection fraction, T2DM results in impaired relaxation and increased fibrosis of the right atrium, with preserved myocardial contractile function. The novel finding of increased expression of SERCA2a:phospholamban ratio suggests a compensatory mechanism to enhance relaxation and maintain diastolic function of the fibrotic atrial myocardium.
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Regis LambertsShivanjali LingamHeng-Yu WangIlse BollenGillian HughesIvor GalvinRichard BuntonAndrew BahnRajesh KatareJ BaldiMichael WilliamsPankaj SaxenaSean CoffeyPeter Jones Source Type: research
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