Brain-derived neurotrophic factor (BDNF) in the rostral anterior cingulate cortex (rACC) contributes to neuropathic spontaneous pain-related aversion via NR2B receptors.
In conclusion, our results demonstrate that the BDNF/TrkB-mediated signaling pathway in the rACC is involved in the development of neuropathic spontaneous pain-related aversion and that this process is dependent upon activation of NR2B receptors. These findings suggest that suppression of the BDNF-related signaling pathway in the rACC may provide a novel strategy to overcome pain-related aversion.
PMID: 27575004 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - Category: Neurology Authors: Zhang L, Wang G, Ma J, Liu C, Liu X, Zhan Y, Zhang M Tags: Brain Res Bull Source Type: research
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