Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure

Conclusion
These data show that the SR Ca2+ leak is lower in women than in men with comparable cardiac impairment. Since the SR Ca2+ leak triggers delayed afterdepolarizations, our findings may explain why women are less prone to ventricular arrhythmias and confirm the rationale of therapeutic measures reducing the SR Ca2+ leak.

Source: Europace - August 30, 2016 Category: Cardiology Authors: Fischer, T. H., Herting, J., Eiringhaus, J., Pabel, S., Hartmann, N. H., Ellenberger, D., Friedrich, M., Renner, A., Gummert, J., Maier, L. S., Zabel, M., Hasenfuss, G., Sossalla, S. Tags: BASIC SCIENCE Source Type: research