Q. why sprironolactone not given in HCM?

Q.Why spironolactone is not given in Hypertrophic cardiomyopathy while other diuretics can help?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums

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ConclusionMachine learning-based texture analysis of late gadolinium-chelate enhancement-positive areas is a promising tool for the classification of hypertrophic cardiomyopathy patients with and without VT.
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
RASopathies are a group of rare genetic diseases caused by germline mutations in genes involved in the RAS–mitogen-activated protein kinase (RAS-MAPK) pathway. Whole-exome sequencing (WES) is a powerful approach for identifying new variants in coding and noncoding DNA sequences, including miRNAs. miRNAs are fine-tuning negative regulators of gene expression. The presence of variants in miRNAs could lead to malfunctions of regulation, resulting in diseases. Here, we identified 41 variants in mature miRNAs through WES analysis in five patients with previous clinical diagnosis of RASopathies syndromes. The pathways, bio...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 9 November 2019Source: Artificial Intelligence in MedicineAuthor(s): Amir Talaei-Khoei, Madjid Tavana, James M. WilsonAbstractChronic diseases often cause several medical complications. This paper aims to predict multiple complications among patients with a chronic disease. The literature uses single-task learning algorithms to predict complications independently and assumes no correlation among complications of chronic diseases. We propose two methods (independent prediction of complications with single-task learning and concurrent prediction of complications with multi-task learning) an...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Condition:   Hypertrophic Cardiomyopathy Intervention:   Diagnostic Test: Non-invasive ECG imaging - CardioInsight test Sponsors:   Imperial College London;   Imperial College Healthcare NHS Trust;   Medtronic;   Barts & The London NHS Trust;   University of Oxford;   Daniel Bagshaw Trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 6 November 2019Source: Molecular Genetics and MetabolismAuthor(s): Susana Peralta, Adrián González-Quintana, Marta Ybarra, Aitor Delmiro, Rafael Pérez-Pérez, Jorge Docampo, Joaquín Arenas, Alberto Blázquez, Cristina Ugalde, Miguel A. MartínAbstractLethal neonatal encephalopathies are heterogeneous congenital disorders that can be caused by mitochondrial dysfunction. Biallelic large deletions in the contiguous ATAD3B and ATAD3A genes, encoding mitochondrial inner membrane ATPases of unknown function, as well as compound heterozygous nonsense...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
AbstractHypertrophic cardiomyopathy (HCM) with severe diastolic dysfunction is a major cause of heart failure and sudden cardiac death (SCD) associated with lethal arrhythmia. Although various risk factors for cardiac events have been reported in HCM patients, previous studies have reported that some HCM patients exhibit either no risk or a low risk of SCD experienced cardiac events. The mid-diastolic transmitral flow velocity curve (mitral L-wave) is an echocardiographic index of left ventricular compliance, and it has been reported as one of the parameters of advanced diastolic dysfunction assessed noninvasively. However...
Source: Heart and Vessels - Category: Cardiology Source Type: research
(University of Virginia Health System) Researchers have revealed the initial results from the world's largest comprehensive study of hypertrophic cardiomyopathy, an abnormal thickening of the heart that often goes undiagnosed and can prove deadly. The condition can present at any age, and it is the most common cause of sudden cardiac death in young athletes.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Condition:   Hypertrophic Cardiomyopathy Intervention:   Device: Stereotactic body radiation therapy Sponsors:   Barts & The London NHS Trust;   Barts Cardiovascular CTU (Queen Mary University of London);   Barts Charity Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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