Study of Alteration in Binding Affinity of RUNX1 with DNA because of Mutations Present in Acute Myeloid Leukemia Patients, and Change in its Direct/Indirect Gene Expression Level

To study the effect of two commonly known mutations i.e. K83E and R174Q in the binding of RUNX1 (involved in acute myeloid leukemia) with DNA and variation in gene expression level of its direct/indirect targeted genes.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research