Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice

Publication date: 15 October 2016 Source:Physiology & Behavior, Volume 165 Author(s): Susan A. Farr, Michael L. Niehoff, Michael A. Ceddia, Kelli A. Herrlinger, Brandon J. Lewis, Shulin Feng, Andrew Welleford, D. Allan Butterfield, John E. Morley Oxidative damage is one of the hallmarks of the aging process. The current study evaluated effects of two proprietary antioxidant-based ingredients, rosemary extract and spearmint extract containing carnosic acid and rosmarinic acid, respectively, on learning and memory in the SAMP8 mouse model of accelerated aging. The two rosemary extracts contained carnosic acid (60% or 10% carnosic acid) and one spearmint extract contained 5% rosmarinic acid. Three doses of actives in each extract were tested: 32, 16, 1.6 or 0mg/kg. After 90days of treatment mice were tested in T-maze foot shock avoidance, object recognition and lever press. Rosemary extract containing 60% carnosic acid improved acquisition and retention in T-maze foot shock, object recognition and lever press. Rosemary extract with 10% carnosic acid improved retention in T-maze foot shock avoidance and lever press. Spearmint with 5% rosmarinic acid improved acquisition and retention in T-maze foot shock avoidance and object recognition. 4-hydroxynonenal (HNE) was reduced in the brain cortex after treatment with all three extracts (P<0.001) compared to the vehicle treated SAMP8. Protein carbonyls were reduced in the hippocampus after administration of ro...
Source: Physiology and Behavior - Category: Physiology Source Type: research