Prevalence of Pneumocystis jirovecii colonization in autopsy cases in Turkey.

Prevalence of Pneumocystis jirovecii colonization in autopsy cases in Turkey. J Med Microbiol. 2016 Aug 19; Authors: Ozkoc S, Koker M, Onder M, Delibas SB Abstract Detection of Pneumocystis jirovecii (P. jirovecii) and its DNA in clinically asymptomatic people is defined as colonization. The aim of this study was to reveal the colonization prevalence of P. jirovecii and affecting factors in an immunocompetent population. The study included 200 cases undergoing forensic autopsy between February 2015 and April 2015. The cause of death was non-medical conditions (group 1) in 111 cases (55.5%), medical conditions (group 2) in 73 cases (36.5%) and was undetermined (group 3) in 16 cases (group 3). Tissue specimens about 1 gr in weight were taken from the right upper pulmonary lobe. After DNA extraction, nested-PCR (nPCR) targeting mitochondrial large subunit ribosomal RNA (mt-LSUrRNA) was used to detect P. jirovecii. Out of 200 cases, 37 (18.5%) had P. jirovecii DNA. There was not a significant difference in place of living, gender, smoking status and medication use between the cases with P. jirovecii and those without P. jirovecii. A significantly high rate of P. jirovecii colonization was detected in group 2 (c²=7.674; p=0.022). P. jirovecii colonized cases had also a chronic disease in two out of 13 (group 1), 12 out of 20 (group 2) and one out of four (group 3) cases (c²=5.571; p=0.062). A significantly high rate of the cases aged 0-...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research