Genetic evolution in chronic lymphocytic leukaemia

Publication date: Available online 11 August 2016 Source:Best Practice & Research Clinical Haematology Author(s): Julio Delgado, Neus Villamor, Armando López-Guillermo, Elías Campo Next-generation sequencing provides a comprehensive understanding of the genomic, epigenomic and transcriptomic underpinnings of chronic lymphocytic leukaemia. Recent studies have uncovered new drivers, including mutations in non-coding regions, and signalling pathways whose role in cancer was previously unknown or poorly understood. Moreover, massive scale epigenomics and transcriptomics have supplied the foundations for the cellular origin of the disease. Some drivers could be targeted pharmacologically, and the ability to detect mutations present in minority subclones might even allow treatment before clonal selection occurs, thus preventing disease refractoriness. As our understanding broadens and ongoing technological innovation propels new achievements, we will certainly learn how to apply it in our daily practice.
Source: Best Practice and Research Clinical Haematology - Category: Hematology Source Type: research