Adenosine and ventricular fibrillation

Adenosine induced ventricular fibrillation has been reported in two situations: During intracoronary administration for assessment of fractional flow reserve (FFR) Intravenous administration in an attempt to identify the mechanism of wide QRS tachycardia Adenosine induced ventricular fibrillation during FFR estimation Three cases of ventricular fibrillation (VF) during intracoronary administration for induction of maximal hyperemia was observed by Shah AH et al [1]. They could prevent future occurrences by doubling the concentration in order to reduce the volume of injection by half. Similar instance of adenosine induced VF during FFR assessment has been reported by Khan ZA et al in a single case [2]. Adenosine induced VF after administration in an attempt to identify the mechanism of wide QRS tachycardia Several cases of adenosine induced VF when given for supraventricular tachycardia or atrial fibrillation have been reported [3-5]. Gupta AK and colleagues reported 4 cases of VF after administration of 12 mg adenosine in preexcited atrial fibrillation which had presented as wide QRS tachycardia [6]. They noted that this phenomenon occurred in accessory pathways with a short refractory period. Parham WA and associates reported adenosine induced VF in a patient with stable ventricular tachycardia [7]. Adenosine had been administered as a therapeutic challenge in a wide QRS tachycardia of uncertain nature. It was later proved to be ventricular tachycardia at electrophysiol...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs