Polyclonal localized light chain amyloidosis - a distinct entity?

Amyloidosis is a rare disease of protein misfolding that results in the deposition of insoluble fibrils mainly in the extracellular spaces of tissues and organs. There are currently over 30 distinct proteins currently known to cause amyloidosis in humans.1 Any organs can be involved although the most clinically relevant ones are the heart, kidneys, nerves, liver, and gastrointestinal tract.2 Amyloid deposition can be systemic wherein there is involvement of multiple organs (e.g., monoclonal immunoglobulin light chain or AL) or diffuse involvement of an organ like the kidneys (e.g., lysozyme variants or ALys).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research