Cancer-associated fibroblast suppresses killing activity of natural killer cells through downregulation of poliovirus receptor (PVR/CD155), a ligand of activating NK receptor.

This study demonstrated a novel mechanism of suppression of NK cell activity by CAFs in the TME.
PMID: 27499237 [PubMed - as supplied by publisher]

Source: International Journal of Oncology - July 25, 2016 Category: Cancer & Oncology Authors: Inoue T, Adachi K, Kawana K, Taguchi A, Nagamatsu T, Fujimoto A, Tomio K, Yamashita A, Eguchi S, Nishida H, Nakamura H, Sato M, Yoshida M, Arimoto T, Wada-Hiraike O, Oda K, Osuga Y, Fujii T Tags: Int J Oncol Source Type: research