Screening of Natural Products and Derivatives for Identification of RND Efflux Pump Inhibitors.

CONCLUSION: p-Coumaric acid and its derivative, 4-(4-((Z)-2-carboxy-2-((Z)-2,3-dihydrobenzo[e][1,4]diazepin-1-yl)-1-(4-hydroxyphenyl)vinylamino)phenylsulfonamido)-2-hydroxybenzoic acid may be used as potential lead molecules for effective RND efflux pump inhibition in P. aeruginosa.
PMID: 27450181 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - July 19, 2016 Category: Chemistry Authors: Choudhury D, Talukdar AD, Chetia P, Bhattacharjee A, Choudhury MD Tags: Comb Chem High Throughput Screen Source Type: research