Historical Study (1986-2014): Improvements in Nutritional Status of Dialysis Patients
Malnutrition is common in dialysis patients and is associated with adverse clinical outcomes. Despite an increased focus on improved nutrition in dialysis patients, it is claimed that the prevalence of malnutrition in this group of patients has not changed during the last decades. Direct historical comparisons of the nutritional status of dialysis patients have never been published. To directly compare the nutritional status of past and current dialysis patients, we implemented the methodology of a study from 1986 on a population of dialysis patients in 2014.
CONCLUSION: This study aims to introduce erythrocytes as appropriate carriers for FVIII to prolong the dosing intervals in the effective and safe levels for a relatively longer time. PMID: 31533604 [PubMed - as supplied by publisher]
Abstract Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease that is characterized by primary ciliary dysfunction (ciliopathy) and progresses to end-stage kidney disease (ESKD) during the second decade of life (juvenile and adolescent NPHP) or before the age of 3 years (infantile NPHP). Here we describe the case of an infant with NPHP who carries a homozygous mutation in SDCCAG8 (also called NPHP10 or BBS16) that encodes SDCCAG8 (serologically defined colon cancer antigen 8). SDCCAG8 is localized at the centrioles of both renal epithelial cells and retinal photoreceptor cells. A mutation in SDC...
Conclusion: These results indicate that device type may affect RHF incidence and mortality. Studies at other centers are needed to replicate these findings. PMID: 31528128 [PubMed]
Publication date: Available online 18 September 2019Source: Protein Expression and PurificationAuthor(s): Nazimuddin Khan, Jino Park, William L. Dean, Robert D. Gray, William Tse, Donghan Lee, T. Michael SaboAbstractThe protein ALL1 fused from chromosome 1q (AF1q) is overexpressed in a variety of cancers and acts to activate several signaling pathways that lead to oncogenesis. For example, AF1q has been shown to interact with T-cell Factor 7 (TCF7; also known as TCF1) from the Wnt/β-catenin pathway resulting in the transcriptional activation of the CD44 and the enhancement of breast cancer metastasis. Despite the impo...
ConclusionsArrhythmias, including clinically significant abnormal rhythms, were common. Tachyarrhythmias were more frequent during dialysis and the immediate postdialytic period. The relevance of these findings to clinical outcomes requires additional study.
The ISN and Kidney International recently introduced the ISN-KI Editorial Fellowship, which is designed specifically for early career researchers working within the field of nephrology, dialysis, and kidney transplantation. The purpose of this Fellowship is to provide training opportunities for the review and critical evaluation of manuscripts and the management of editorial responsibilities within the context of a high-impact nephrology journal. We are delighted and proud to announce the 2 winners of our 2019 Fellowships.
This report is the first systematic review of the distal revascularization with interval ligation (DRIL) procedure using standardized quality assessment methodology (Oxford critical appraisal skills and recommendation for practice using National Institute for Health and Care Excellence checklist). In this study, 22 publications with 459 patients with dialysis access steal syndrome (DASS) treated with DRIL were analyzed.1 The conclusion was that the DRIL procedure is an effective treatment for various grades of DASS.
It is widely accepted that an autogenous arteriovenous fistula is preferred over arteriovenous grafts and/or central venous catheters for dialysis access. To create an arteriovenous fistula, an adequate vein and artery are required. In many patients who require vascular access, the forearm cephalic vein has been damaged owing to multiple venotomies and/or intravenous catheterizations. Thus, the vein is often scarred or occluded, negating the first-line radiocephalic fistula. The forearm basilic vein lies in a medial position, making it more difficult to access for venipuncture or placement of intravenous lines.
In this study, Ramanan and colleagues1 have attempted to shed light on this difficult area of vascular practice. They conclude that “if feasible,” open revascularization should be considered an option for limb salvage in end-stage renal disease patients with CLI because of its association with a lower risk of major limb amputation, in spite of the higher rate of bleeding and wound complications, compared with endovascular re vascularization.
We present the initial pre-clinical study results of a novel, self-sealing, immediate cannulation dialysis graft that aims to prevent needle-related complications; to promote safe, reliable needle access; to reduce catheter use; and could facilitate home hemodialyisis. METHODS: The innovative graft design consists of two cannulation chambers with self-sealing properties and materials that prevent side and back wall needle puncture. Study and control grafts (expanded polytetrafluoroethylene) were implanted in one pig and 10 sheep in two studies over the course of 1 year. First cannulation occurred immediately pos...