SePARating thrombosis and hemostasis?

Heart attack and ischemic stroke, which commonly arise from thrombotic occlusions, are the world-leading causes of death and a major health burden. In most cases, the rupture or erosion of an unstable atherosclerotic plaque, which results in the exposure of thrombogenic extracellular matrix proteins, triggers arterial thrombosis [14]. Under these conditions, platelets, which circulate in the blood stream, become captured and activated by extracellular matrix proteins. Inevitably, platelet activation leads to thrombus formation at sites of damage via the action of platelet integrins, predominantly αIIbβ3, and the presence of a pro-coagulant surface for the initiation of the coagulation cascade.
Source: Thrombosis Research - Category: Hematology Authors: Tags: Editorial Source Type: research