Long QT Syndrome Associated With a Mutation in the β3 Subunit of the Cardiac Sodium Channel (SCN3B) Gene in Two Siblings

Abstract: A 22-year-old female who was 10 weeks post-partum received successful resuscitation by her husband and defibrillation from QAS following out-of-hospital cardiac arrest during sleep with documented ventricular fibrillation. 12-lead ECG following arrest showed prolonged QTc 500ms. Echocardiography revealed mildly dilated left ventricle and moderate systolic dysfunction (EF 35-40%) with preserved basal function, which normalised within seven days. CT pulmonary angiogram, cardiac catheter study and cardiac MRI were normal.

Source: Heart, Lung and Circulation - July 27, 2016 Category: Cardiology Authors: K. Lau, P. Martin, K. Chia, J. McGaughran, J. Atherton Tags: 664 Source Type: research