Na+, HCO3--cotransporter NBCn1 increases pHi gradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling

Conclusion Under physiological conditions (i.e. with CO2/HCO3– present), NBCn1-mediated HCO3– uptake raises VSMC pHi and promotes filopodia, VSMC migration, and hypertrophic inward remodelling. We propose that axial pHi gradients enhance VSMC migration whereas global acidification inhibits VSMC proliferation and media hypertrophy after carotid artery ligation. These findings support a key role of acid–base transport, particularly via NBCn1, for development of occlusive artery disease.
Source: Cardiovascular Research - Category: Cardiology Authors: Tags: Vascular Biology Source Type: research