Human Basic Fibroblast Growth Factor Inhibits Tau Phosphorylation via the PI3K/Akt-GSK3 β Signaling Pathway in a 6-Hydroxydopamine-Induced Model of Parkinson's Disease

Conclusion: < /i > < /b > Liposomes markedly assisted in the delivery of bFGF to the brain and enhanced the neuroprotective effects of bFGF by inhibiting the phosphorylation of tau. bFGF down-regulated the phosphorylation of tau by increasing the phosphorylation of GSK3 β via the PI3K/Akt signaling pathway. These findings provide a new vision of bFGF as a potential therapy for PD. < br / > Neurodegener Dis 2016;16:357-369
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research