John Daly Lecture: Marine Microorganisms Provide Access to New Drug Targets for the Treatment of Cancer

John Daly Lecture This year’s John W. Daly Memorial Lecture is “Marine Microorganisms Provide Access to New Drug Targets for the Treatment of Cancer” by William Fenical, Ph.D., Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography. Daly was a noted natural products chemist and pharmacologist in NIDDK who died in 2008 Marine microorganisms, and in particular marine actinomycete bacteria, are a genetically-unique and chemically-rich source for the discovery of new drug leads. The development of novel isolation and culture methods has allowed access to a variety of previously uncultured strains that now form the foundation for innovative cancer drug discovery efforts. Examining this new chemical source and coupling it with a program to identify new intracellular protein targets has provided several new and unpredicted pathways that can be exploited for cancer treatment. Cytotoxic marine microbial metabolites such as the ammosamides, marinopyrroles, napyradiomycins, and more recently the seriniquinones, show binding affinity to a diversity of new protein targets, illustrating that new approaches exist to treating various cancers. These and more recent discoveries will form the content of this presentation.Air date: 7/15/2016 1:00:00 PM
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