[Correspondence] Phenytoin for neuroprotection

Rhian Raftopoulos and colleagues1 reported that, compared with placebo, patients allocated to phenytoin treatment displayed a 30% reduction in thinning of the retinal nerve fibre layer (RNFL) evaluated with optical coherence tomography at 6 months in eyes with acute optic neuritis relative to baseline values of unaffected eyes. The study has methodological issues as discussed in the Comment,2 but here we raise the relevant question of whether the issue is an absence of demonstrated clinical benefit or of appropriate outcomes to measure thisbenefit.

Source: Lancet Neurology - July 12, 2016 Category: Neurology Authors: Elena H Martinez-Lapiscina, Magi Andorra, Bernardo Sanchez-Dalmau, Pablo Villoslada Tags: Correspondence Source Type: research