Brigham and Women's Hospital's Experience Correlating Cytogenetic and Sequencing Panel Results for Management of Myeloid Disorders

Myeloid disorders are a heterogeneous group of hematologic neoplasms that includes acute myeloid leukemia, myelodysplastic syndromes and myeloproliferative neoplasms. Cytogenetic testing has long served as a primary tool for risk stratification of myeloid disorders. However, a significant proportion of cases exhibit a normal karyotype and outcomes often vary among individuals with the same abnormal karyotype. Molecular genetic analysis in myeloid disorders has led to the discovery of recurrent somatic driver mutations, which allow for further risk stratification within cytogenetic groups as well as among the normal karyotype group.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research