Gender disparity in LDL-induced cardiovascular damage and the protective role of estrogens against electronegative LDL

DNA damage and endothelial senescence observed in male db/db mice maybe partly attributed to the presence of more electronegative LDL. Furthermore, estrogens provide hormonal protection against the harmful effects of electronegative LDL, and gender disparities in LDL electronegativity may impact the development of coronary disease.

Source: Cardiovascular Diabetology - March 25, 2014 Category: Cardiology Authors: An-Sheng LeeWei-Yu ChenHua-Chen ChanJing-Fang HsuMing-Yi ShenChia-Ming ChangHenry BairMing-Jai SuKuan-Cheng ChangChu-Huang Chen Source Type: research