Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma [Melanoma]

Conclusion
Adoptive cell transfer can mediate durable complete regressions in 24% of patients with metastatic melanoma, with median survival > 3 years. Results were similar using chemotherapy preparative regimens with or without addition of TBI.

Source: Journal of Clinical Oncology - June 30, 2016 Category: Cancer & Oncology Authors: Goff, Dudley, Citrin, Somerville, Wunderlich, Danforth, Zlott, Yang, Sherry, Kammula, Klebanoff, Hughes, Restifo, Langhan, Shelton, Lu, Kwong, Ilyas, Klemen, Payabyab, Morton, Toomey, Steinberg, White, Rosenberg Tags: Translational Oncology, Melanoma, Immunology/Immunobiology Source Type: research