Physiologic Variations in Blood Plasminogen Levels Affect Outcomes after Acute Cerebral Thromboembolism in Mice: A Pathophysiologic Role for Microvascular Thrombosis

ConclusionsVariation in blood plasminogen levels, within the range seen in normal individuals, had marked effects on experimental ischemic brain injury. Higher plasminogen levels protected against ischemic brain injury, decreased blood‐brain barrier breakdown, matrix metalloproteinase‐9 expression and microvascular thrombosis. The protective effects of blood plasminogen appear to be mediated largely through reduction of microvascular thrombosis in the ischemic territory.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Original Article ‐ Fibrinolysis Source Type: research