A case-control study to identify environmental risk factors for hand, foot, and mouth disease outbreaks in beijing.

A case-control study to identify environmental risk factors for hand, foot, and mouth disease outbreaks in beijing. Jpn J Infect Dis. 2014;67(2):95-9 Authors: Xiaona W, Ying S, Changying L, Lei J, Qingrui W, Xinyu L, Quanyi W Abstract A matched case-control study was conducted in Beijing to identify the relative importance of major environmental risk factors for outbreaks of hand, foot, and mouth disease (HFMD). A case was defined as a kindergarten class with at least 1 HFMD outbreak. As a control, a kindergarten class that did not experience an HFMD outbreak was used. To identify potential transmission factors, the control group was divided into 2 subgroups: a sporadic group and an HFMD-negative group. We collected data for 8 environmental factors and basic information of each class. The correlations between the suspected environmental factors and HFMD outbreaks were analyzed. Thirty outbreak classes, 19 sporadic classes, and 30 HFMD-negative classes were enrolled. Class grade, indoor solar radiation, and ultraviolet (UV) radiation revealed significant differences among the 3 groups. After controlling for other factors, UV radiation (adjusted β = -0.42) and class grade (adjusted β = -0.46) as protective factors and temperature (adjusted β = 0.31) as a risk factor were significantly associated with the attack rate by multiple linear regression analysis. Logistic regression analysis showed that the probability of an HFMD outbreak in the lowe...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research