Sequence variation of dengue type 2 virus isolated from clinical cases in Thailand.

In this study, the sequence diversity of the envelope gene of 8 DENV-2 clinical isolates from primary/secondary infections was analyzed. DENV-2 from primary infections were highly heterogeneous in individual patients, whereas those from secondary infections were homogeneous. Phylogenetic analysis demonstrated that the heterogeneous population of DENV-2 from primary infections was composed of closely related quasispecies. Homogenous DENV-2 could be derived from selection of a particular viral population in secondary infections. The degree of sequence diversity of DENV-2 varied, and thus quasispecies may be involved in the progression of DENV infection. PMID: 24647259 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/24647259?dopt=Abstract

Source: Japanese Journal of Infectious Diseases - March 23, 2014 Category: Infectious Diseases Authors: Kurosu T, Chaichana P, Phanthanawiboon S, Khamlert C, Yamashita A, A-Nuegoonpipat A, Ikuta K, Anantapreecha S Tags: Jpn J Infect Dis Source Type: research