Dr Le Fanu's online health clinic, Friday 21st March 2014

Concerned about aches and pains? Worried about a medical condition? You can email your questions confidentially to Dr Le Fanu at drjames@telegraph.co.uk. Answers will be published in the health section of the Telegraph website every Friday. Today: the statin debate continues, discontinued migraine drugs, side-effects of shingles vaccine and cough syncope    
Source: The Telegraph : Health Advice - Category: Consumer Health News Source Type: news

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In conclusion, BLU-5937 was selected as a drug candidate for the treatment of chronic cough due to its high potency and selectivity for P2X3 homotrimeric receptors, strong anti-tussive effects, excellent tolerability and predicted pharmacokinetic properties in humans.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
In conclusion, clinical presentation at time of diagnosis of brain metastases consistently includes neurologic signs and symptoms with persistent headache being the most common. Endometrial cancer patients that present with new neurologic complaints or exam findings should be evaluated for brain metastases.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Conclusions: The results indicated that probiotic food and supplement withLactobacillus andBifidobacterium could be used as interventions to improve specific anthropometric and biochemical outcomes among individuals withMetS. However, probiotic treatment alone could not reduce overall health risks. In addition, there were methodological drawbacks among reviewed studies, and further research is needed.Ann Nutr Metab 2019;74:224 –241
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
This article discusses a quality improvement project across four NP-owned primary care clinics in which all clinical staff received an educational intervention focused on best vaccination practices and Medicare billing strategies. This project yielded improved vaccination rates in the older adult patient population over a 3-month period.
Source: The Nurse Practitioner - Category: Nursing Tags: Feature: PREVENTIVE CARE: DNP SPECIAL ISSUE Source Type: research
BEST supplements for cholesterol: Having high cholesterol can pose a huge risk to a person ’s health, so what can you do to lower it? Eating an unhealthy diet is one of the main causes of the condition, but some research has shown certain vitamins, minerals and natural substances can lower high cholesterol levels.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
We report a case of bilateral CSH in the posterior fossa successfully treated with a single-burr hole surgery. A 74-year-old man under anticoagulation and antiplatelet therapy developed headache and nausea during observation for an asymptomatic supratentorial CSH. Radiological examinations revealed appearance of bilateral CSH in the posterior fossa associated with hydrocephalus. Upon rapid deterioration of the patient ’s consciousness, an urgent treatment was required. A burr hole was made near the transverse-sigmoid junction on the left side to access the hematoma. No ventricular drainage was placed as his conscious...
Source: Case Reports in Neurology - Category: Neurology Source Type: research
Intravenous immunoglobulin therapy is FDA approved for the immune-mediated peripheral nerve disorders Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy. Immunoglobulin therapy has been used increasingly with significant efficacy in the treatment of patients with disabling autoimmune forms of dysautonomia, which are most often small fiber (autonomic and/or sensory) polyneuropathies. It is recognized by most who treat these disorders, however, that patients with autonomic dysfunction treated with intravenous immunoglobulin therapy develop aseptic meningitis or severe ...
Source: European Neurology - Category: Neurology Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Developmental exposure to stress hormones, glucocorticoids, is central to the process of prenatal programming of later life health. Glucocorticoid overexposure, through stress or exogenous glucocorticoids, results in reduced birthweight, as well as affective and neuropsychiatric outcomes in adults, combined with altered hypothalamus-pituitary-adrenal (HPA) axis activity. As such, glucocorticoids are tightly regulated during development through the presence of the metabolising enzyme 11 β-Hydroxysteroid Dehydrogenase type 2 (HSD2). HSD2 is highly expressed in two hubs during development: the placenta and the fetus itse...
Source: Neuroendocrinology - Category: Endocrinology Source Type: research
(MedPage Today) -- Survival at 2 years was 72.4% versus 40.9% with chemotherapy alone
Source: MedPage Today OB/GYN - Category: OBGYN Source Type: news
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