Cancers de la prostate de score de Gleason supérieur ou égal à 8: Evaluation de la survie des patients

Conclusion Les cancers de la prostate de score de Gleason ≥ 8 sont de mauvais pronostic dans notre pratique. Objectives To evaluate the oncological outcomes of patients treated for prostate cancer Gleason score ≥ 8 using as criteria: total PSA, overall survival and progression-free survival. Patients and methods This was a retrospective study in the Urology-andrology department of the Aristide Le Dantec hospital in Dakar, from 1st June 2010 - to October 31, 2014. We compiled the data of 30 patients with prostate cancer with a Gleason score ≥ 8. The treatments used were hormonal therapy and radical prostatectomy. Results The median initial PSA level was 97.7ng/ml (2-32,047ng/ml). Prostate cancer was found in the metastatic phase in over half the cases (83.3%). The treatment was hormonal in 82.8% of cases. Median survival was 14 months and the average overall survival time was 13.18 months. The overall survival of the standard 6, 12, and 24 months was respectively 72.7, 54.5 and 0.9%. PFS at 3, 14 and 21 months was respectively 50, 16.7 and 8.3%. Conclusion Prostate cancer with Gleason score ≥ 8 has a poor prognosis in our practice.
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research