Delivery strategies and potential targets for siRNA in major cancer types.

Delivery strategies and potential targets for siRNA in major cancer types.
Adv Drug Deliv Rev. 2016 May 31;
Authors: Lee SJ, Kim MJ, Kwon IC, Roberts TM
Abstract
Small interfering RNA (siRNA) has gained attention as a potential therapeutic reagent due to its ability to inhibit specific genes in many genetic diseases. For many years, studies of siRNA have progressively advanced toward novel treatment strategies against cancer. Cancer is caused by various mutations in hundreds of genes including both proto-oncogenes and tumor suppressor genes. In order to develop siRNAs as therapeutic agents for cancer treatment, delivery strategies for siRNA must be carefully designed and potential gene targets carefully selected for optimal anti-cancer effects. In this review, various modifications and delivery strategies for siRNA delivery are discussed. In addition, we present current thinking on target gene selection in major tumor types.
PMID: 27259398 [PubMed - as supplied by publisher]

Source: Advanced Drug Delivery Reviews - May 30, 2016 Category: Drugs & Pharmacology Authors: Lee SJ, Kim MJ, Kwon IC, Roberts TM Tags: Adv Drug Deliv Rev Source Type: research