IL-27 plasma level in relapsing remitting multiple sclerosis subjects: The double-faced cytokine.

IL-27 plasma level in relapsing remitting multiple sclerosis subjects: The double-faced cytokine. J Immunoassay Immunochem. 2016 Jun 1; Authors: Naderi S, Hejazi Z, Shajarian M, Alsahebfosoul F, Etemadifar M, Sedaghat N Abstract Interleukin-27 (IL-27) is a member of IL-6/IL-12 cytokine family which possesses pro- and anti-inflammatory properties and participates in the pathogenesis of various autoimmune diseases. In our case-control study, plasma was collected from healthy subjects as control group (n=40) and patients with relapsing-remitting multiple sclerosis (RRMS) (n=40), including new identified cases without treatment (n=12) and those treated with Interferon beta (IFN-β) (n=28). The plasma level of IL-27 was assessed by ELISA method. Our results indicated that plasma level of IL-27 in MS patients increased significantly compared to the control subjects (p=0.027). Furthermore, after parting case group into the two sub-groups, results revealed a significant difference of IL-27 plasma levels between control group and treated patients (p<0.001), but not about that of between healthy subjects and untreated MS patients (p=0.259). Also, mean levels of IL-27 in treated and untreated patients showed a significant difference (P=0.007). These results demonstrate the possible modulation of IL-27 during autoimmune disease in human which may suggest the suppressive or therapeutic role of IL-27 on inflammatory diseases. PMID: 2724...
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research