Abstract A46: A bone marrow vascular niche model to study the effects of a DNA Damage Secretory Program in promoting prostate cancer treatment resistance

Conclusions: These studies suggest that effectors derived from the bone marrow vascular niche are differentially regulated following DNA-damage. Subsequently, those factors may influence tumor cell proliferation and/or resistance to therapy, but may do so in a tumor cell-specific manner. Characterization of the DDSP from the vascular niche could potentially unravel mechanisms of treatment resistance and tumor progression.Citation Format: Christine Levesque, Xin Zhao, Cyrus M. Ghajar, Peter S. Nelson. A bone marrow vascular niche model to study the effects of a DNA Damage Secretory Program in promoting prostate cancer treatment resistance. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr A46.
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Tumor Dormancy and Resistance Source Type: research