Polycystic kidney disease: Cilia and mechanosensation revisited

Nature Reviews Nephrology 12, 318 (2016). doi:10.1038/nrneph.2016.61 Authors: Alexis Hofherr & Michael Köttgen Polycystic Kidney disease (PKD) is caused by mutations in genes that affect cilia structure and composition. Impaired mechanosensation through primary cilia has been proposed as a pathogenic mechanism in PKD; however, a new study challenges this hypothesis by showing an absence of mechanically induced Ca2+ increases in primary cilia.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: News and Views Source Type: research