Coumarin Derivatives as Adjuvants: From In Silico Physicochemical Characterization to In Vitro Evaluation against Gram Positive Bacteria.

CONCLUSION: The data support the potential use of acylated coumarin derivatives as next generation adjuvants as evaluated by their in silico ADMET analysis and in vitro antibacterial and cytotoxicity evaluation. Further research involving these combinations is warranted.
SIGNIFICANCE AND IMPACT OF THE STUDY: This study suggests that acylated coumarin derivatives act as antibacterial adjuvants in combination with standard drugs and have potential to be used in pharmaceutical preparations.
PMID: 27151485 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - May 5, 2016 Category: Chemistry Authors: Phougat N, Chhillar AK, Prasad AK, Senapati NN, Khatri S, Kumar M, Srivastava S, Dabur R Tags: Comb Chem High Throughput Screen Source Type: research