Novel therapeutic approaches for chronic kidney disease due to glomerular disorders.

Novel therapeutic approaches for chronic kidney disease due to glomerular disorders.
Am J Physiol Renal Physiol. 2016 May 4;:ajprenal.00245.2016
Authors: Del Nogal-Avila M, Donoro-Blazquez H, Saha MK, Marshall CB, Clement LC, Macé CE, Chugh SS
Abstract
Improved understanding of glomerular disease mechanisms over the past decade has led to the emergence of new and targeted therapeutic strategies for chronic kidney disease (CKD). Most promising among these are the administration of recombinant mutated human Angiopoietin-like 4, sialic acid related sugars that induce sialylation in vivo, compounds related to Bis-T-23, and immune-depletion of the soluble urokinase receptor from the circulation. Taking these therapeutic strategies into clinical trials will be the first step away from repurposed and relatively toxic drugs currently used for treating kidney disease.
PMID: 27147672 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - May 3, 2016 Category: Urology & Nephrology Authors: Del Nogal-Avila M, Donoro-Blazquez H, Saha MK, Marshall CB, Clement LC, Macé CE, Chugh SS Tags: Am J Physiol Renal Physiol Source Type: research