Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis [Basic Sciences]

Conclusions— Our results provide the basis needed for the design of future preclinical studies on recanalization therapies using this model of thromboembolic stroke in mice. The power analysis reveals that a multicenter trial would require 123 animals per group instead of 40 for a single-center trial.

http://stroke.ahajournals.org/cgi/content/short/47/5/1312?rss=1

Source: Stroke - April 24, 2016 Category: Neurology Authors: Orset, C., Haelewyn, B., Allan, S. M., Ansar, S., Campos, F., Cho, T. H., Durand, A., El Amki, M., Fatar, M., Garcia-Yebenes, I., Gauberti, M., Grudzenski, S., Lizasoain, I., Lo, E., Macrez, R., Margaill, I., Maysami, S., Meairs, S., Nighoghossian, N., Or Tags: Animal Models of Human Disease, Ischemic Stroke Basic Sciences Source Type: research