Number of Ribs Resected is Associated with Respiratory Complications Following Lobectomy with en bloc Chest Wall Resection

Conclusions In patients undergoing lobectomy with en bloc chest wall resection for non-small cell lung cancer, the number of ribs resected is directly associated with incidence of postoperative respiratory complications.
Source: Lung - Category: Respiratory Medicine Source Type: research

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The aim of this study was to determine the role of physiological measurements in the evaluation of postoperative risks before lung cancer surgery. Spirometry and ABG were performed for all patients with NSCLC before operation. Diffusion test and CPET were performed to patients with moderate-high risk for operation and the patient who required pneumonectomy. Postoperative complications, mortality and duration of stay in ICU and hospital were recorded.115 NSCLC patients who had limited lung capacity(22F,93M) with a mean age of 62.37±10.11 were included prospectively between Jan2015-Dec2018. 54(46.9%) patients were acc...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Thoracic surgery Source Type: research
Conclusion: Despite some disadvantages of videothoracoscopic surgery for large lung cancer, like less mobilization of the tumor and a reduced operating space, VATS lobectomy is a safe and technically feasible procedure even in for lung cancer of>5-cm diameter in experienced hands.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Thoracic surgery Source Type: research
Conclusions: We found that samples of EBC groups of healthy donors, patients with BA, COPD, pneumonia and NSCLC have a characteristic protein spectrum. The identified proteins could be offered as a diagnostic panel for these diseases based on EBC analysis. The identified peptides have been used for developing a diagnostic model for EBC proteomic data.The study was supported by RFBR (project no. 18-29-09158).
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Objective: Investigate the effect of smoking cessation timing on the Enhanced Recovery After Surgery program in terms of postoperative pulmonary complication (PPC) rate and hospital length of stay (LOS) after videothoracoscopic (VATS) lobectomy for lung cancer patients.Methods: Patients with early stage non-small cell lung carcinoma who underwent VATS lobectomy between January 2017 and 2019 were enrolled, prospectively. Relationship between timing of smoke cessation in ERAS program and PPC incidence was studied by 2 cohorts: Group 1 consisted of non-smokers or patients who quitted ≥4 weeks before operation. Group 2 cons...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Thoracic surgery Source Type: research
Background and objective In recent years, a number of clinical trials have shown that immunocheckpoint inhibitors (ICI) have brought survival benefits to patients with advanced non-small cell lung cancer (NSCLC), however, such clinical trials comprise cohorts selected based on strict and complex entry and exclusion criteria, and the results cannot fully reflect the real world situation. The purpose of this study was to investigate the clinical efficacy and safety of immunotherapy in the real world, as well as possible prognostic factors. Methods Patients with advanced NSCLC receiving immunotherapy in Beijing Chest Hospital...
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
Conclusion Radiation with SIB intensity modulated radiotherapy technique is effective and safe for patients with locally advanced NSCLC. DOI: 10.3779/j.issn.1009-3419.2019.11.03
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
AbstractThe safety of anti-programmed cell death 1 (PD-1) antibody for patients with preexisting interstitial lung disease (ILD) remains unknown. The aim of this study was to evaluate the dependence of preexisting ILD on anti-PD-1 antibody-induced pneumonitis in non-small cell lung cancer (NSCLC) patients. We retrospectively reviewed the association of preexisting ILD with the incidence, radiographic pattern, and outcome of pneumonitis in NSCLC patients receiving anti-PD-1 antibody. A total of 331 patients were included in this study. Of these patients, 17 had preexisting ILD. The incidence of pneumonitis was higher among ...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
The last decade has seen a transition in the surgical approach to lobectomy, from thoracotomy to minimally invasive surgery (MIS), for treating patients with early-stage non-small cell lung cancer (NSCLC) [1]. Growing evidence has demonstrated that MIS lobectomy, including video-assisted thoracic surgery (VATS) and robotic-assisted thoracic surgery (RATS), is associated with fewer postoperative complications such as arrhythmias and pneumonia and shorter chest tube duration and length of hospital stay [2 –8].
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
This study was performed to investigate the clinical and radiologic characteristics and risk factors of ALK-IIP in patients with non-small cell lung cancer (NSCLC). A total of 250 NSCLC patients who had been treated with ALK inhibitors were retrospectively enrolled. Chest computed tomography (CT) was classified into 4 CT patterns using the 2013 guideline for idiopathic interstitial pneumonia: cryptogenic organizing pneumonia (COP), hypersensitivity pneumonitis (HP), acute interstitial pneumonia (AIP), and nonspecific interstitial pneumonia. Clinical characteristics including toxicity grading and treatment course were anal...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Conclusion: Atezolizumab 1,200 mg and pembrolizumab 2 mg/kg every 3 weeks were ordinarily safer than other ICIs. When treating NSCLC, nivolumab had the lowest risk; when treating melanoma, pembrolizumab had the lowest toxicity.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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