Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis

Conclusions
We demonstrate that nintedanib effectively inhibits the endogenous as well as cytokine-induced activation of SSc fibroblasts and exerts potent antifibrotic effects in different complementary mouse models of SSc. These data have direct translational implications for clinical trials with nintedanib in SSc.

Source: Annals of the Rheumatic Diseases - April 6, 2016 Category: Rheumatology Authors: Huang, J., Beyer, C., Palumbo-Zerr, K., Zhang, Y., Ramming, A., Distler, A., Gelse, K., Distler, O., Schett, G., Wollin, L., Distler, J. H. W. Tags: Immunology (including allergy), Interstitial lung disease, Connective tissue disease Basic and translational research Source Type: research