Clinical and immunological features and outcome of anti-p200 pemphigoid.

CONCLUSION: Many patients with anti-p200 pemphigoid had heterogeneous clinical presentation, and a more severe prognosis than previously suspected. This article is protected by copyright. All rights reserved. PMID: 27037896 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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This study used a population-based medical dataset to explore the association between previously diagnosed psoriasis and dementia in Taiwan.MethodsUsing the Taiwan Longitudinal Health Insurance Database 2000, we identified 7118 individuals with a diagnosis of dementia; a further 21,354 sex- and aged-matched individuals were randomly extracted as controls. Patients with bullous pemphigoid, which is characterized by inflammatory phenomena similar to that evident in psoriasis, were chosen as a control group. Conditional logistic regression was performed to evaluate the association between dementia and prior psoriasis or bullo...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
Publication date: Available online 5 December 2018Source: SeizureAuthor(s): Man Amanat, Roland Thijs, Mona Salehi, Josemir W. SanderAbstractThe risk of epileptic seizures seems increased in several systemic autoimmune disorders including systemic lupus erythematosus, type 1 diabetes mellitus, myasthenia gravis, celiac disease, rheumatoid arthritis, Hashimoto’s encephalopathy, psoriasis, multiple sclerosis, neuromyelitis optica, and bullous pemphigoid. Immune dysfunction may be partly responsible for this association. Elevated levels of pro-inflammatory cytokines, autoantibodies seen in these autoimmune disorders and ...
Source: Seizure - Category: Neurology Source Type: research
This case report describes a 43-year-old man with psoriasis and mucous membrane pemphigoid who received treatment with baricitinib.
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research
Abstractω3‐polyunsaturated free fatty acids (ω3‐PUFAs), particularly docosahexaenoic (DHA) and eicosapentaenoic acid (EPA), are thought to exert health promoting effects in metabolic and in inflammatory diseases. The molecular mechanisms of these beneficial effects are only partially understood. DHA a nd EPA activateFree Fatty Acid receptor 4 (GPR120/FFA4). Recently, the first orally available, synthetic ligand of FFA4, 3 ‐[2‐chloro‐5‐(trifluoromethoxy)phenyl]‐3‐azaspiro[5.5]undecane‐9‐acetic acid (“compound A”; cpd A) has been developed. Cpd A exhibits distinctly higher potency,...
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
hmidt E Abstract IL-17A has been identified as key regulatory molecule in several autoimmune and chronic inflammatory diseases followed by the successful use of anti-IL-17 therapy, e.g. in ankylosing spondylitis and psoriasis. Bullous pemphigoid (BP) is the most frequent autoimmune blistering disease with a high need for more specific, effective and safe treatment options. The aim of this study was to clarify the pathophysiological importance of IL-17A in BP. We found elevated numbers of IL-17A+ CD4+ lymphocytes in the peripheral blood of BP patients and identified CD3+ cells as major source of IL-17A in early BP ...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
Australasian Journal of Dermatology, EarlyView.
Source: Australasian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
Abstract Several case reports and cohort studies have recently investigated the potential association between bullous pemphigoid (BP) and psoriasis. It has been speculated that chronic inflammation in the dermo-epidermal junction can trigger exposure to antigens to autoreactive T cells, resulting in autoimmune blistering disease. However, the association described has been inconsistently reported amongst studies. We performed a systematic review and meta-analysis to investigation this potential association. We identified four case-control studies for inclusion in the present meta-analysis, with a total of 4035 bul...
Source: The Australasian Journal of Dermatology - Category: Dermatology Authors: Tags: Australas J Dermatol Source Type: research
In conclusion, this population-based study demonstrates an assoc iation of DPP4i intake with three autoimmune and inflammatory diseases noted to be part of a distinct autoimmune cluster that includes multiple sclerosis, psoriasis, thyroiditis, bullous pemphigoid, and inflammatory bowel disease. Experimental studies are required to define the role of DPP4i in this autoimmune cluster.
Source: Immunologic Research - Category: Allergy & Immunology Source Type: research
Source: European Journal of Dermatology - Category: Dermatology Source Type: research
Of interest, the association of dementia (D) and bullous pemphigoid is well-known, but there is a paucity of literature regarding D association with other inflammatory dermatological conditions. The aim of this study was to determine the prevalence of D in psoriasis patients in a large US patient population by searching a medical record data repository (>5 million patients). The study cohort consisted of all adults aged 40-89 years with a diagnosis of D (all subtypes from Jan 2001 to Nov 2017). ICD9 and ICD10 codes were used to detect psoriasis: 696.1, L40.0, L40.1, L40.2, L40.3, and L40.4; and D: 290, 294, 331, F01, F0...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
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