Clinical and immunological features and outcome of anti-p200 pemphigoid.

CONCLUSION: Many patients with anti-p200 pemphigoid had heterogeneous clinical presentation, and a more severe prognosis than previously suspected. This article is protected by copyright. All rights reserved. PMID: 27037896 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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Dermatitis. 2021 Aug 16. doi: 10.1097/DER.0000000000000776. Online ahead of print.ABSTRACTAs treatment with immune checkpoint inhibitors (CPIs) for cancer increases, so has the incidence of immune-related cutaneous adverse events (irCAEs). These toxicities can significantly impact quality of life and may be dose-limiting. Current guidelines for irCAEs offer only corticosteroids or CPI discontinuation. Evidence supports biologic immunomodulatory therapies when corticosteroids fail or need avoidance. A review of literature from 2010 to 2020 yielded 45 articles, resulting in 185 irCAEs, including bullous pemphigoid-like erupt...
Source: Dermatitis - Category: Dermatology Authors: Source Type: research
J Mol Med (Berl). 2021 Aug 9. doi: 10.1007/s00109-021-02105-y. Online ahead of print.ABSTRACTAdenosine triphosphate-binding cassette subfamily B member 1 (ABCB1), also known as permeability glycoprotein, multidrug-resistant protein 1, or cluster of differentiation 243 (CD243), is a crucial protein for purging foreign substances from cells. The functions of ABCB1 have been investigated extensively for their roles in cancer, stem cells, and drug resistance. Abundant pharmacogenetic studies have been conducted on ABCB1 and its association with treatment responsiveness to various agents, particularly chemotherapeutic and immun...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
AbstractUstekinumab is approved for the treatment of psoriasis and Crohn ’s disease. Because many dermatological conditions are due to immune-mediated development, ustekinumab may be effective in other conditions. A systematic review of the off-label uses of ustekinumab, as well as on-label adverse effect, was performed, reporting on clinical improvement. MEDLINE, Emba se, Web of Science, and Cochrane databases were searched for studies regarding ustekinumab treatment of rativa (HS), lichen planus (LP), pyoderma gangrenosum (PG), pityriasis rubra pilaris (PRP), cutalopecia areata (AA), atopic dermatitis (AD), Bechet&...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
AbstractDipeptidyl-peptidase 4 (DPP4) is a multifunctional type II transmembrane glycoprotein that is expressed on various cell surfaces. While DPP4 inhibitors have a therapeutic role in the treatment of diabetes mellitus, they are an independent risk factor in the development of bullous pemphigoid. Contrarily, there are reports of improvement in psoriasis with DPP4 inhibition. We investigated the effect of DPP4 inhibition on primary human keratinocytes to determine whether DPP4 modulates keratinocyte inflammatory signaling and keratinocyte homeostasis. We performed RNA sequencing of primary adult human keratinocytes treat...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
Conclusions: This study expanded the ability of FFOCT for the clinical diagnosis of various skin conditions. This new optical technique can clearly visualise skin lesions located in the epidermis and upper dermis. It provided an effective way to perform digital skin biopsy in superficial skin diseases.Dermatology
Source: Dermatology - Category: Dermatology Source Type: research
Human inflammation activates dynamically, but the mechanisms underlying such sensitive kinetics remain incompletely understood. We single-cell profiled transcriptomes and epitopes from 24 diverse rashes in adults, including psoriasis, atopic dermatitis, lichen planus, and bullous pemphigoid. The tristetraprolin family members ZFP36 and ZFP36L2 were identified as recurrently, highly repressed transcripts in T cells (logeFC = -0.47 and -0.85 respectively; adjPvals
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research
This report highlights the potential of irreversible nail damage occurring in reportedly benign nail conditions like psoriasis and trachyonychia, emphasizing the need for early recognition and aggressive management in such cases.Skin Appendage Disord
Source: Skin Appendage Disorders - Category: Dermatology Source Type: research
Source: European Journal of Dermatology - Category: Dermatology Source Type: research
Dipeptidyl peptidase 4 (DPP-4) is widely expressed in keratinocytes as well as many other tissues. Although the impact of DPP-4 inhibition has been well characterized in systems, its direct impact on skin remains unclear. Recently, the use of DPP-4 inhibition is associated with an increased risk of developing bullous pemphigoid through what is thought to be an immune mediated mechanism. In contrast, DPP-4 inhibition appears beneficial in psoriasis. To elucidate the effect of DPP-4 inhibition in keratinocytes, we performed RNA-seq using a small molecular inhibitor of DPP-4.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Extracellular vesicles (EVs), naturally secreted by almost all known cell types into extracellular space, can transfer their bioactive cargos of nucleic acids and proteins to recipient cells, mediating cell-cell communication. Thus, they participate in many pathogenic processes including immune regulation, cell proliferation and differentiation, cell death, angiogenesis, among others. Cumulative evidence has shown the important regulatory effects of EVs on the initiation and progression of inflammation, autoimmunity, and cancer. In dermatology, recent studies indicate that EVs play key immunomodulatory roles in inflammator...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
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