Video-Assisted Needle Core Biopsy in Children Affected by Neuroblastoma: A Novel Combined Technique

Conclusions The video-assisted needle-core biopsy combines minimally invasive surgery several advantages with the possibility to obtain multiple samples in different regions with minimal tumor exposition and low complication rate.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text
Source: European Journal of Pediatric Surgery - Category: Surgery Authors: Tags: Original Article Source Type: research

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AbstractPurposePancreatic tumors are rare in children and limited data are available regarding incidence, treatment, and outcomes. We aim to describe patient and tumor characteristics and to report on survival of these diseases.MethodsChildren with pancreatic tumors were queried from the National Cancer Database (2004 –2014). The association between treatment and hazard of death was assessed using Kaplan–Meier method and Cox regression model.ResultsWe identified 109 children with pancreatic tumors; 52% were male and median age at diagnosis was 14  years. Tumors were distributed as follows: pseudopapillary ...
Source: Pediatric Surgery International - Category: Surgery Source Type: research
AbstractInformative and realistic mouse models of high-risk neuroblastoma are central to understanding mechanisms of tumour initiation, progression, and metastasis. They also play vital roles in validating tumour drivers and drug targets, as platforms for assessment of new therapies and in the generation of drug sensitivity data that can inform treatment decisions for individual patients. This review will describe genetically engineered mouse models of specific subsets of high-risk neuroblastoma, the development of patient-derived xenograft models that more broadly represent the diversity and heterogeneity of the disease, ...
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
Neuroblastoma (NB) is the most common malignant extracranial solid tumor in children. Despite significant survival improvements in multiple pediatric malignancies, children with relapsed neuroblastoma (NB) have dismal outcomes. ROR1 is highly expressed on the majority of NB (Rebagay/Yan Front Oncol, 2012). Our group has successfully expanded functional and active peripheral blood NK cells (exPBNK) with irradiated feeder cells and electroporated CAR mRNA to exPBNK (Chu/Cairo, et al, Can Imm Res 2015).
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 385 Source Type: research
Conditions:   Refractory Cancer;   Refractory Neoplasm;   Cancer Pediatric;   Refractory Tumor;   Pediatric Cancer;   Pediatric Brain Tumor;   Neuroblastoma;   Neuroblastoma Recurrent;   Pediatric Lymphoma;   Pediatric Meningioma Interventions:   Drug: 9-ING-41;   Drug: Irinotecan Sponsors:   Actuate Therapeutics Inc.;   Developmental Therapeutics Consortium Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Neuroblastoma;   Pediatric Solid Tumor Interventions:   Procedure: Tissue collection;   Biological: GVAX vaccine;   Drug: Nivolumab;   Drug: Ipilimumab Sponsor:   Dana-Farber Cancer Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Refractory Cancer;   Refractory Neoplasm;   Cancer Pediatric;   Refractory Tumor;   Pediatric Cancer;   Pediatric Brain Tumor;   Neuroblastoma;   Neuroblastoma Recurrent;   Pediatric Lymphoma;   Pediatric Meningioma Interventions:   Drug: 9-ING-41;   Drug: Irinotecan Sponsors:   Actuate Therapeutics Inc.;   Developmental Therapeutics Consortium Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Neuroblastoma;   Pediatric Solid Tumor Interventions:   Procedure: Tissue collection;   Biological: GVAX vaccine;   Drug: Nivolumab;   Drug: Ipilimumab Sponsor:   Dana-Farber Cancer Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Refractory Cancer;   Refractory Neoplasm;   Cancer Pediatric;   Refractory Tumor;   Pediatric Cancer;   Pediatric Brain Tumor;   Neuroblastoma;   Neuroblastoma Recurrent;   Pediatric Lymphoma;   Pediatric Meningioma Interventions:   Drug: 9-ING-41;   Drug: Irinotecan Sponsors:   Actuate Therapeutics Inc.;   Developmental Therapeutics Consortium Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Neuroblastoma;   Pediatric Solid Tumor Interventions:   Procedure: Tissue collection;   Biological: GVAX vaccine;   Drug: Nivolumab;   Drug: Ipilimumab Sponsor:   Dana-Farber Cancer Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Refractory Cancer;   Refractory Neoplasm;   Cancer Pediatric;   Refractory Tumor;   Pediatric Cancer;   Pediatric Brain Tumor;   Neuroblastoma;   Neuroblastoma Recurrent;   Pediatric Lymphoma;   Pediatric Meningioma Interventions:   Drug: 9-ING-41;   Drug: Irinotecan Sponsors:   Actuate Therapeutics Inc.;   Developmental Therapeutics Consortium Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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