The number of persons with symptomatic knee osteoarthritis in the United States: Impact of race/ethnicity, age, sex, and obesity

Conclusion: Over half of all persons with symptomatic knee OA are younger than 65 years of age. As many of these younger persons will live for three decades or more, there is substantially more time for greater disability to occur and policymakers should anticipate healthcare utilization for knee OA to increase further in upcoming decades. These data emphasize the need for the deployment of innovative prevention and treatment strategies for knee OA, especially among younger persons. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Original Article Source Type: research

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Publication date: Available online 15 October 2019Source: Stem Cell ResearchAuthor(s): Tomoyuki Kurose, Shinya Takahashi, Takashi Otsuka, Kei Nakagawa, Takeshi Imura, Taijiro Sueda, Louis YugeAbstractSpinal cord ischemia is a potential complication of thoracoabdominal aortic surgery that may induce irreversible motor disability. We investigated the therapeutic efficacy of simulated microgravity-cultured mesenchymal stem cell (MSC) injection following spinal cord ischemia−reperfusion injury. Sprague-Dawley rats were divided into sham, phosphate-buffered saline (PBS), normal gravity-cultured MSC (MSC-1G), and simulated...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 15 October 2019Source: Stem Cell ResearchAuthor(s): Nina V. Fuchs, Maximilian Schieck, Michaela Neuenkirch, Christiane Tondera, Heike Schmitz, Vincent des Portes, David Germanaud, Doris Steinemann, Gudrun Göhring, Renate KönigAbstractThe Renpenning syndrome spectrum is a rare X-linked mental retardation syndrome characterized by intellectual disability, microcephaly, low stature, lean body and hypogonadism. Mutations in the polyglutamine tract binding protein 1 (PQBP1) locus are causative for disease. Here, we describe the generation of an iPSC line from a patient mutated in the...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Authors: Penzenstadler L, Molodynski A, Khazaal Y Abstract Objectives: The Convention on the Rights of Persons with Disabilities (CRPD) was adopted at the United Nations Assembly in 2006. The main aim of the convention is to ensure equal rights for people with disabilities including the expression of people's own "will and preferences" concerning health treatment. Article 12 demands the respect of a person's "rights, will and preferences" (CRPD) and suggests supported decision making (SDM) when possible. The aim of this review was to gather information regarding the SDM implementation from a cli...
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
Publication date: January 2020Source: LWT, Volume 118Author(s): Vítor Spínola, Eulogio J. Llorent-Martínez, Paula C. CastilhoAbstractIn this work, we report the in vitro inhibitory potential of Rumex maderensis methanolic extracts (leaves, flowers, and stems) towards key digestive enzymes linked to type-2 diabetes and obesity (α-amylase, α-glucosidase, pancreatic lipase). The inhibitory activity towards aldose reductase and glycation of bovine serum albumin (BSA) is also reported; in these latter assays, the effect of simulated digestion on the bioactivities was evaluated. The inhibitory ac...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: Bariatric surgery when combined with dietary and exercise changes gave significant results in terms of weight loss, knee pain and function. It is an approach that tackles both obesity and OA. It is a major step forward in stemming the global epidemic of these two interlinked conditions.
Source: Journal of Minimal Access Surgery - Category: Surgery Authors: Source Type: research
ConclusionMore than half of all persons with symptomatic knee OA are younger than 65 years of age. As many of these younger persons will live for 3 decades or more, there is substantially more time for greater disability to occur, and policymakers should anticipate health care utilization for knee OA to increase in the upcoming decades. These data emphasize the need for the deployment of innovative prevention and treatment strategies for knee OA, especially among younger persons.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Original Article Source Type: research
ConclusionDue to the aging of the population, OA will remain a major and growing health issue in Canada over the next 2 decades, regardless of the course of the obesity epidemic.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Osteoarthritis Source Type: research
NHS data has shown that the number of hip replacement operations on people aged under 60 has risen 76% in the last decade. More and more people under the age of 60 are turning to hip replacement surgery as a remedy for chronic hip pain, according to new NHS data. The Royal College of Surgeons has analysed statistics released by the Health &Social Care Information Centre showing that hip replacements are becoming more common among younger patients, which is indicative of growing confidence in this type of treatment. The growing demand for hip replacements According to the data, there were 89,919 hip replacement operatio...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news
Conclusions. Due to the aging of the population, OA will remain a major and growing health issue in Canada over the next two decades, regardless of the course of the obesity epidemic. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Original Article Source Type: research
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