Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility

Conclusion The present study is a comprehensive study demonstrating that upregulation of MMP activity can induce a downregulation of expression of NKG2D ligands in gastric cancer cells, leading to lower-level susceptibility to NK cells.

http://link.springer.com/10.1007/s00535-016-1197-x

Source: Journal of Gastroenterology - March 21, 2016 Category: Gastroenterology Source Type: research