Mechanisms and Consequences of Aneuploidy and Chromosome Instability in the Aging Brain

We describe the mechanisms accountable for an abnormal DNA content with a particular emphasis on the CNS where cell division is limited. Next, we briefly summarize the types of GIN known to date and discuss how they interconnect with CIN. Lastly we highlight how several forms of CIN may contribute to genetic variation, tissue degeneration and disease in the CNS.
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research